O=C(Nc1cncc2ccccc12)C1CC=Nc2ccc(Cl)cc21
O=C(Nc1cncc2ccccc12)C1OC=Nc2ccc(Cl)cc21
O=C1N(c2cncc3ccccc23)NCC12CCOc1ccc(Cl)cc12
O=C(Nc1cncc2ccccc12)C1CC=Nc2c1[nH]c(Cl)cc2=O
O=C(Nc1cncc2ccccc12)C1CCOc2c1[nH]c(Cl)cc2=O
O=C1CC2(CCOc3ccc(Cl)cc32)C(=O)N1c1cncc2ccccc12
CN1C(=O)N(c2cncc3ccccc23)C(=O)C12CCOc1ccc(Cl)cc12
3D Modeling (MOE). Decreasing conformational strain and rotatable bonds while increasing H-bonding potential.