Submission Details

TOB-UNK-c2aba166
Molecule(s):
C#CCN1CCN(C(=O)CCl)CC1

TOB-UNK-c2aba166-1

C#CCN1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Made Check Availability on Manifold View
C#CCN1CCN(C(=O)C=C)CC1

TOB-UNK-c2aba166-2

C#CCN1CCN(C(=O)C=C)CC1

C#CCN1CCN(S(=O)(=O)C=C)CC1

TOB-UNK-c2aba166-3

C#CCN1CCN(S(=O)(=O)C=C)CC1

C#CCN1CCN(S(=O)(=O)/C=C/c2ccccc2)CC1

TOB-UNK-c2aba166-4

C#CCN1CCN(S(=O)(=O)/C=C/c2ccccc2)CC1

C=CS(=O)(=O)N1CCN(Cc2cn(-c3ccc4nc[nH]c4c3)nn2)CC1

TOB-UNK-c2aba166-5

C=CS(=O)(=O)N1CCN(Cc2cn(-c3ccc4nc[nH]c4c3)nn2)CC1

C#CC1CCCN(S(=O)(=O)C=C)C1

TOB-UNK-c2aba166-6

C#CC1CCCN(S(=O)(=O)C=C)C1

C=CS(=O)(=O)N1CCCC(c2cn(-c3ccc4nc[nH]c4c3)nn2)C1

TOB-UNK-c2aba166-7

C=CS(=O)(=O)N1CCCC(c2cn(-c3ccc4nc[nH]c4c3)nn2)C1

Design Rationale:

Creation of a covalent Click-Chemistry library with variation of the covalent warhead. Inspired by previous compounds ANT-STE-dbb with focus on warhead variation due to borderline biocompatibility of chloracetamides.

Inspired By:
Discussion:

Contributor: Tobias Grabe - Thu, 02 Apr 2020 12:18:25 +0000