Submission Details
Molecule(s):
C=CC(=O)NC(C(=O)NCc1ccccc1)c1cccnc1
C=CC(=O)NC(C(=O)NCc1ccc(C(F)(F)F)cc1)c1cccnc1
C=CC(=O)NC(C(=O)NCc1ccc(Br)cc1)c1cccnc1
C=CC(=O)NC(C(=O)NCC)c1cccnc1
C=CC(=O)NC(C(=O)NC(C)C)c1cccnc1
C=CC(=O)NC(C(=O)NCCC)c1cccnc1
C=CC(=O)NC(C(=O)NCc1cc2ccccc2[nH]1)c1cccnc1
C=CC(=O)NC(C(=O)NCc1ccc2ccccc2c1)c1cccnc1
C=CC(=O)NC(C(=O)NCc1cc2ccccc2o1)c1cccnc1
C=CC(=O)NC(C(=O)NCC1CCCCC1)c1cccnc1
C=CC(=O)NC(C(=O)NCC1CCCC1)c1cccnc1
C=CC(=O)NC(C(=O)NCC1CCCC1=O)c1cccnc1
C=CC(=O)NC(C(=O)NCc1ccc[nH]1)c1cccnc1
C=CC(=O)NC(C(=O)NCc1cncs1)c1cccnc1
C=CC(=O)NC(C(=O)NCc1cnco1)c1cccnc1
C=CC(=O)NC(C(N)=O)c1cccnc1
Design Rationale:
Creating a common pharmacophore from most active inhibitors from wave 1 which is an Enamine REAL compound. Analogues created by alkylating the pharmacophore.