Submission Details

NIM-UNI-bb610069
Molecule(s):
O=C(Cn1cc(CN(C(=O)CCl)C2CCS(=O)(=O)C2)nn1)Nc1cccnc1

NIM-UNI-bb610069-1
Duplicate of:
NIM-UNI-594fbbb6-1

O=C(Cn1cc(CN(C(=O)CCl)C2CCS(=O)(=O)C2)nn1)Nc1cccnc1

Duplicate 3-aminopyridine-like Check Availability on Manifold View
O=C(CCl)N(Cc1cnnn1Cc1ccc(Cl)cc1)C1CCS(=O)(=O)C1

NIM-UNI-bb610069-2
Duplicate of:
NIM-UNI-594fbbb6-2

O=C(CCl)N(Cc1cnnn1Cc1ccc(Cl)cc1)C1CCS(=O)(=O)C1

NS(=O)(=O)c1cccc(-n2cc(CN3CCN(C(=O)CCl)CC3)nn2)c1

NIM-UNI-bb610069-3
Duplicate of:
NIM-UNI-594fbbb6-3

NS(=O)(=O)c1cccc(-n2cc(CN3CCN(C(=O)CCl)CC3)nn2)c1

Duplicate piperazine-chloroacetamide Ordered Check Availability on Manifold View
Design Rationale:

Joining together fragments using click chemistry

Other Notes:

Resubmitting designed but with an alpha chloro group so they become covalent inhibitors.

Inspired By:
Discussion:

Contributor: Nimesh Mistry, University of Leeds - Tue, 31 Mar 2020 08:09:08 +0000