Submission Details
Molecule(s):
O=C(Oc1cncc(C(F)(F)F)c1)c1cccc2[nH]ccc12
Clc1cncc(OCc2cccc3[nH]ccc23)c1
Clc1cncc(COc2cccc3[nH]ccc23)c1
O=C(Nc1cccc2[nH]ccc12)c1cncc(Cl)c1
CN(C(=O)c1cncc(Cl)c1)c1cccc2[nH]ccc12
O=C(Oc1cc(F)cc(Cl)c1)c1cccc2[nH]ccc12
Clc1cncc(CCc2cccc3[nH]ccc23)c1
O=C(Oc1cncc(Cl)c1)c1cccc2c1ccn2C(=O)CCl
Design Rationale:
Some modification of the active molecule ALP-POS-c59291d4-5, in order to explore the linker, the chloroaryl mojety and the combination with an irreversible inhibitor