Submission Details
Molecule(s):
CC(=O)CC1CCN(c2cccnc2)C(=O)N1c1cccnc1
CC(=O)CCN(C(=O)N(C)c1cccnc1)c1cccnc1
Design Rationale:
Goal is to combine the non covalent interaction of X0434 with the common demeaner of the covalent fragments, the acetyle function. The hexahydropyrimidine is employed to facilitate the correct orientation. However a chain might facilitate entry into the cavity and have beneficial flexibility. This probably comes at the cost of having to protect the second amine, though (e.g. with a methyl group). The chain length is estimated by eye to two bridging methylene groups to the acetyle function.
Other Notes:
The phenyl group of the X0434 backbone was substituted with a pyridine as the synthesis of a more symmetric molecule might be easier.