Submission Details

EDJ-MED-b774e9fe
Molecule(s):
CC(=O)N1CCc2ccc(Cl)cc2C1C(=O)Nc1cncc2ccccc12

EDJ-MED-b774e9fe-1

CC(=O)N1CCc2ccc(Cl)cc2C1C(=O)Nc1cncc2ccccc12

CS(=O)(=O)N1CCc2ccc(Cl)cc2C1C(=O)Nc1cncc2ccccc12

EDJ-MED-b774e9fe-2

CS(=O)(=O)N1CCc2ccc(Cl)cc2C1C(=O)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
CNS(=O)(=O)N1CCc2ccc(Cl)cc2C1C(=O)Nc1cncc2ccccc12

EDJ-MED-b774e9fe-3

CNS(=O)(=O)N1CCc2ccc(Cl)cc2C1C(=O)Nc1cncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
Design Rationale:

MAT-POS-fb82b63d-1 is 1.1uM similar to the analogous tetrahydroisoquinoline. Explore simple amides and sulfonamides potential to real into S1'. See also crystal structure P0800_0A.

Inspired By:
Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Fri, 27 Aug 2021 13:59:46 +0000