Submission Details

RAL-THA-b74298ba
Molecule(s):
Cn1cnnc1NC(=O)C1CCOc2ccc(Cl)cc21

RAL-THA-b74298ba-1

Cn1cnnc1NC(=O)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
CCn1cnnc1NC(=O)C1CCOc2ccc(Cl)cc21

RAL-THA-b74298ba-2

CCn1cnnc1NC(=O)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
CC(C)n1cnnc1NC(=O)C1CCOc2ccc(Cl)cc21

RAL-THA-b74298ba-3

CC(C)n1cnnc1NC(=O)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1nncn1CCO)C1CCOc2ccc(Cl)cc21

RAL-THA-b74298ba-4

O=C(Nc1nncn1CCO)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Expansion/bioisosteric replacements/scaffold hopping of an early lead JAG-UCB-a3ef7265-20. Simple alkyl replacements for the c-Pr group to help inform the design of triazole replacements for which the corresponding c-Pr monomers may not be available. Hydroxy ethyl analog may assist solubility and by H-bond to Glu 166 or Asn 142.

Inspired By:
Discussion:

Contributor: Ralph Robinson, Thames Pharma Partners - Wed, 24 Jun 2020 22:00:03 +0000