Submission Details

VLA-UNK-a5257d84

Molecule(s):

CO[C@@]1(C(=O)Nc2cncc3ccccc23)COc2cc(F)c(Cl)cc21

VLA-UNK-a5257d84-1

CO[C@@]1(C(=O)Nc2cncc3ccccc23)COc2cc(F)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View

Design Rationale:

Putting it all together, furan ring instead of pyran for lower logP and reduce clearance.

Inspired By:

O=C(Nc1cncc2ccccc12)[C@@H]1COc2ccc(Cl)cc21

EDJ-MED-12c115cc-1

COC1(C(=O)Nc2cncc3ccccc23)CCOc2cc(F)c(Cl)cc21

ALP-POS-fe871b40-11

Discussion:

Contributor: Vladimiras Oleinikovas - Thu, 04 Feb 2021 15:46:01 +0000