Submission Details

ALF-EVA-a24cc7ce
Molecule(s):
O=C(Nc1cccc2cnccc12)C1COc2ccc(Cl)cc21

ALF-EVA-a24cc7ce-1

O=C(Nc1cccc2cnccc12)C1COc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CN(C(=O)C1COc2ccc(Cl)cc21)c1cncc2ccccc12

ALF-EVA-a24cc7ce-2

CN(C(=O)C1COc2ccc(Cl)cc21)c1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2c1CCCC2)C1CCNc2ccccc21

ALF-EVA-a24cc7ce-3

O=C(Nc1cncc2c1CCCC2)C1CCNc2ccccc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1ccc2cncc(F)c2c1)C1COc2ccc(Cl)cc21

ALF-EVA-a24cc7ce-4

O=C(Nc1ccc2cncc(F)c2c1)C1COc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cccc2cnccc12)C1CCOc2c(F)cccc21

ALF-EVA-a24cc7ce-5

O=C(Nc1cccc2cnccc12)C1CCOc2c(F)cccc21

3-aminopyridine-like Check Availability on Manifold View
O=C(NC1CCOc2ccc(Cl)cc21)c1cncc2ccccc12

ALF-EVA-a24cc7ce-6

O=C(NC1CCOc2ccc(Cl)cc21)c1cncc2ccccc12

CN(C(=O)Cc1cc(F)cc(F)c1)c1cncc2ccccc12

ALF-EVA-a24cc7ce-7

CN(C(=O)Cc1cc(F)cc(F)c1)c1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1nccc2cnccc12)C1COc2ccc(Cl)cc21

ALF-EVA-a24cc7ce-8

O=C(Nc1nccc2cnccc12)C1COc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Molecules in REAL Space identified by Evariste's ligand-based screening pipeline. Not expected to be super potent but readily accessible and might be useful for filling SAR gaps.

Discussion:

Contributor: Alfie Brennan, Evariste Technologies - Thu, 13 May 2021 13:40:17 +0000