Submission Details
Molecule(s):
COc1cccc(N2CC3(CN(C(=O)c4cc(=O)[nH]c5ccccc45)C3)C2)c1
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(c2cccc(Cl)c2)CC1
N#Cc1cccc(N2CCN(C(=O)c3cc(=O)[nH]c4ccccc34)CC2)c1
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(c2cccc(C(F)(F)F)c2)CC1
COc1ccccc1NC1CCN(C(=O)c2cc(=O)[nH]c3ccccc23)C1
COc1ccccc1OC1CCN(C(=O)c2cc(=O)[nH]c3ccccc23)C1
O=C(c1cc(=O)[nH]c2ccccc12)N1CCC(N2CCOc3ccccc32)C1
COc1ccccc1NC1CN(C(=O)c2cc(=O)[nH]c3ccccc23)C1
COc1ccccc1OC1CN(C(=O)c2cc(=O)[nH]c3ccccc23)C1
O=C(c1cc(=O)[nH]c2ccccc12)N1CC(N2CCOc3ccccc32)C1
COc1cccc(CN2CCN(C(=O)c3cc(=O)[nH]c4ccccc34)CC2)c1
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(Cc2cccc(Cl)c2)CC1
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(Cc2cccc(C(F)(F)F)c2)CC1
N#Cc1cccc(CN2CCN(C(=O)c3cc(=O)[nH]c4ccccc34)CC2)c1
Design Rationale:
Visual alignment to the crystal structure of MAT-POS-916a2c5a-4