Submission Details
Molecule(s):
N#C/C=C/C[C@@H](c1cccc(C#N)c1)c1ccc(Cl)s1
Design Rationale:
Nitrile michael acceptor. Cool idea: Nitrile N presents a H bond acceptor to DMSO/water pocket. Alkene is available for selective electrophilic attack from cysteine. Thiophene and Cyanophenyl match known binders.
Other Notes:
SMcK-021