Submission Details

Molecule(s):
N#C/C=C/C[C@@H](c1cccc(C#N)c1)c1ccc(Cl)s1

SEA-TRI-74689dea-1

N#C/C=C/C[C@@H](c1cccc(C#N)c1)c1ccc(Cl)s1


Design Rationale:

Nitrile michael acceptor. Cool idea: Nitrile N presents a H bond acceptor to DMSO/water pocket. Alkene is available for selective electrophilic attack from cysteine. Thiophene and Cyanophenyl match known binders.

Other Notes:

SMcK-021

Inspired By:
Discussion: