Submission Details

MIC-UNK-ea4eb352
Molecule(s):
COC1(C(=O)Nc2cncc3ccccc23)CCS(=O)(=O)c2ccc(Cl)cc21

MIC-UNK-ea4eb352-1

COC1(C(=O)Nc2cncc3ccccc23)CCS(=O)(=O)c2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CN(S(C)(=O)=O)Cc2ccc(Cl)cc21

MIC-UNK-ea4eb352-2
Duplicate of:
ALP-POS-5290f14d-1

COC1(C(=O)Nc2cncc3ccccc23)CN(S(C)(=O)=O)Cc2ccc(Cl)cc21

Duplicate 3-aminopyridine-like Ordered Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CCNc2ccc(Cl)cc21

MIC-UNK-ea4eb352-3

COC1(C(=O)Nc2cncc3ccccc23)CCNc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CCSc2ccc(Cl)cc21

MIC-UNK-ea4eb352-4

COC1(C(=O)Nc2cncc3ccccc23)CCSc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CCS(=O)(=O)c2cc(Cl)c(Cl)cc21

MIC-UNK-ea4eb352-5

COC1(C(=O)Nc2cncc3ccccc23)CCS(=O)(=O)c2cc(Cl)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CN(S(C)(=O)=O)Cc2cc(Cl)c(Cl)cc21

MIC-UNK-ea4eb352-6

COC1(C(=O)Nc2cncc3ccccc23)CN(S(C)(=O)=O)Cc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CCNc2cc(Cl)c(Cl)cc21

MIC-UNK-ea4eb352-7
Duplicate of:
EDJ-MED-4f704dc9-1

COC1(C(=O)Nc2cncc3ccccc23)CCNc2cc(Cl)c(Cl)cc21

Duplicate 3-aminopyridine-like Ordered Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CCSc2cc(Cl)c(Cl)cc21

MIC-UNK-ea4eb352-8

COC1(C(=O)Nc2cncc3ccccc23)CCSc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CCS(=O)(=O)c2cc(F)c(Cl)cc21

MIC-UNK-ea4eb352-9

COC1(C(=O)Nc2cncc3ccccc23)CCS(=O)(=O)c2cc(F)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CN(S(C)(=O)=O)Cc2cc(F)c(Cl)cc21

MIC-UNK-ea4eb352-10

COC1(C(=O)Nc2cncc3ccccc23)CN(S(C)(=O)=O)Cc2cc(F)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CCNc2cc(F)c(Cl)cc21

MIC-UNK-ea4eb352-11
Duplicate of:
ALP-POS-fe871b40-12

COC1(C(=O)Nc2cncc3ccccc23)CCNc2cc(F)c(Cl)cc21

Duplicate 3-aminopyridine-like Ordered Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CCSc2cc(F)c(Cl)cc21

MIC-UNK-ea4eb352-12

COC1(C(=O)Nc2cncc3ccccc23)CCSc2cc(F)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

I've picked six-membered ring systems that replacing chromane increase potency, then added methoxy, second chlorine or fluorine. Some of these were submitted previously

Inspired By:
Discussion:

Contributor: Michal K - Mon, 03 May 2021 19:16:29 +0000