O=C(Nc1cncc2ccccc12)[C@]12OCC[C@H]1COc1ccc(Cl)cc12
O=C(Nc1cncc2ccccc12)[C@]12OCO[C@H]1COc1ccc(Cl)cc12
O=C(Nc1cncc2ccccc12)[C@]12COC[C@H]1COc1ccc(Cl)cc12
O=C(Nc1cncc2ccccc12)[C@H]1c2cc(Cl)ccc2CN2[C@@H]1CCCS2(=O)=O
O=C(Nc1cncc2ccccc12)[C@H]1c2cc(Cl)ccc2CN2[C@@H]1CCS2(=O)=O
Same idea as in EDJ-MED-e4b030d8-11, while making whole thing stiffer Compound 2 could be made (perhaps) from MAT-POS-0c8fa4a7-1, compound 3, maybe, via 3+2 cycloaddition