Submission Details

JOH-UNI-e398da21
Molecule(s):
CSC1(C(=O)Nc2cncc3ccccc23)CNC(=O)c2ccc(Cl)cc21

JOH-UNI-e398da21-1

CSC1(C(=O)Nc2cncc3ccccc23)CNC(=O)c2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CSC1(C(=O)Nc2cncc3ccccc23)CN(S(C)(=O)=O)Cc2ccc(Cl)cc21

JOH-UNI-e398da21-2
Duplicate of:
MIC-UNK-6e9f8a43-1

CSC1(C(=O)Nc2cncc3ccccc23)CN(S(C)(=O)=O)Cc2ccc(Cl)cc21

Duplicate 3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Would a S enable a sigma hole interatcion and comformationally lock this?

Other Notes:

SMe vs OMe bioisoster examples.

Discussion:

Contributor: John Spencer, Uni of Sussex - Sat, 05 Jun 2021 11:09:08 +0000