Submission Details


Design Rationale:

adds to earlier series and also looks to target nearby Cys by either covalent or non covalent attachment- see Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs. Bauer, M. R., Jones, R., Baud, M. G. J., Wilcken, R.; Boeckler, F. M., Fersht, A. R., Joerger, A. C.*, Spencer, J.* ACS Chem. Biol. 2016, 11, 2265−2274.

Inspired By: