Submission Details
Molecule(s):
MIK-NEW-9ae4bfeb-1
Duplicate of:
BRU-THA-a358fbdd-4
CC1(C(=O)Nc2nncn2C2CC2)CCOc2ccc(Cl)cc21
Design Rationale:
Most potent compound so far, JAG-UCB-a3ef7265-20, crystal structure shows active conformation has the amide in the axial position, which will be the less stable conformer. Adding the methyl group will increase the conformational preference for the active conformation. If possible to make homochirally, the active enantiomer should be the R-configuration.