Submission Details

SEA-TRI-98d2cd42

Molecule(s):

C=CC(=O)N1CCN(Cc2cc(Cl)cc3cccc(OCCN4CCN(C)CC4)c23)CC1

SEA-TRI-98d2cd42-1

C=CC(=O)N1CCN(Cc2cc(Cl)cc3cccc(OCCN4CCN(C)CC4)c23)CC1

Check Availability on Manifold View

Design Rationale:

Extension of fragment hit. Lipophilic pocket utilised. Switch cysteine reactive group to michael acceptor Added solubiliser

Other Notes:

SMcK-019

Inspired By:

O=C(CCl)N1CCN(Cc2cccc3ccccc23)CC1

MED-COV-4280ac29-31

Discussion:

Contributor: Sean McKenna, Trinity College Dublin - Thu, 02 Apr 2020 10:13:53 +0000