Submission Details

MAT-POS-97ec4bd1
Molecule(s):
COC1(CS(=O)(=O)N2Cc3ccc(Cl)cc3C(C(=O)Nc3cncc4ccc(C(C)(C)O)cc34)C2)CC1

MAT-POS-97ec4bd1-1

COC1(CS(=O)(=O)N2Cc3ccc(Cl)cc3C(C(=O)Nc3cncc4ccc(C(C)(C)O)cc34)C2)CC1

3-aminopyridine-like Assayed Check Availability on Manifold View
CC(C)(O)c1ccc2cncc(NC(=O)C3CN(S(=O)(=O)CC4(C#N)CC4)Cc4ccc(Cl)cc43)c2c1

MAT-POS-97ec4bd1-2

CC(C)(O)c1ccc2cncc(NC(=O)C3CN(S(=O)(=O)CC4(C#N)CC4)Cc4ccc(Cl)cc43)c2c1

3-aminopyridine-like Assayed Check Availability on Manifold View
CNC(=O)CN1Cc2ccc(Cl)cc2C(C(=O)Nc2cncc3ccc(C(C)(C)O)cc23)C1

MAT-POS-97ec4bd1-3

CNC(=O)CN1Cc2ccc(Cl)cc2C(C(=O)Nc2cncc3ccc(C(C)(C)O)cc23)C1

3-aminopyridine-like Assayed Check Availability on Manifold View
CNC(=O)CN1CC(C(=O)Nc2cncc3ccc(C(C)(C)O)cc23)c2cc(Cl)ccc2C1=O

MAT-POS-97ec4bd1-4

CNC(=O)CN1CC(C(=O)Nc2cncc3ccc(C(C)(C)O)cc23)c2cc(Cl)ccc2C1=O

Design Rationale:

Further analogs of the C(C)(C)(OH) 6 position isoquinoline, to probe metabolism

Discussion:

Contributor: Matt Robinson, PostEra - Thu, 23 Sep 2021 04:35:36 +0000