Submission Details

EDJ-MED-93390d0c
Molecule(s):
CS(=O)(=O)c1ccc2cncc(NC(=O)C3CCS(=O)(=O)c4ccc(Cl)cc43)c2c1

EDJ-MED-93390d0c-1

CS(=O)(=O)c1ccc2cncc(NC(=O)C3CCS(=O)(=O)c4ccc(Cl)cc43)c2c1

3-aminopyridine-like Check Availability on Manifold View
CS(=O)(=O)c1ccc2c(NC(=O)C3CCS(=O)(=O)c4ccc(Cl)cc43)cncc2c1

EDJ-MED-93390d0c-2

CS(=O)(=O)c1ccc2c(NC(=O)C3CCS(=O)(=O)c4ccc(Cl)cc43)cncc2c1

3-aminopyridine-like Assayed Check Availability on Manifold View
CO[C@]1(C(=O)Nc2cncc3cc(S(C)(=O)=O)ccc23)CCOc2cc(F)c(Cl)cc21

EDJ-MED-93390d0c-3

CO[C@]1(C(=O)Nc2cncc3cc(S(C)(=O)=O)ccc23)CCOc2cc(F)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CO[C@]1(C(=O)Nc2cncc3ccc(S(C)(=O)=O)cc23)CCOc2cc(F)c(Cl)cc21

EDJ-MED-93390d0c-4

CO[C@]1(C(=O)Nc2cncc3ccc(S(C)(=O)=O)cc23)CCOc2cc(F)c(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

permutation of iv cassette compounds with best exposure in mouse. Variation of isoquinoline sulphone position

Inspired By:
Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Mon, 26 Apr 2021 13:53:35 +0000