Submission Details

RAL-THA-901e9a10
Molecule(s):
Cc1cc(CC(=O)Nc2cnccc2C)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-1

Cc1cc(CC(=O)Nc2cnccc2C)cc(OC2CC(=O)N2)c1

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1cc(F)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-2

Cc1ccncc1NC(=O)Cc1cc(F)cc(OC2CC(=O)N2)c1

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1cc(C#N)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-3
Duplicate of:
TRY-UNI-2eddb1ff-6

Cc1ccncc1NC(=O)Cc1cc(C#N)cc(OC2CC(=O)N2)c1

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
C#Cc1cc(CC(=O)Nc2cnccc2C)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-4

C#Cc1cc(CC(=O)Nc2cnccc2C)cc(OC2CC(=O)N2)c1

3-aminopyridine-like Check Availability on Manifold View
COc1cc(CC(=O)Nc2cnccc2C)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-5

COc1cc(CC(=O)Nc2cnccc2C)cc(OC2CC(=O)N2)c1

3-aminopyridine-like Check Availability on Manifold View
CCc1cc(CC(=O)Nc2cnccc2C)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-6

CCc1cc(CC(=O)Nc2cnccc2C)cc(OC2CC(=O)N2)c1

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1cccc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-7
Duplicate of:
BRU-LEF-c49414a7-1

Cc1ccncc1NC(=O)Cc1cccc(OC2CC(=O)N2)c1

Duplicate 3-aminopyridine-like Made Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1ccc(Cl)c(OC2CC(=O)N2)c1

RAL-THA-901e9a10-8

Cc1ccncc1NC(=O)Cc1ccc(Cl)c(OC2CC(=O)N2)c1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Follow up of beta-lactam TRY-UNI-2eddb1ff-7 (pIC50 = 5.4 in the fluorescence protease assay): Exploration of substituents projecting into the P2 pocket, i.e., replacement of chloro by small and medium-sized subsituents.

Discussion:

Contributor: Ralph Robinson, Thames Pharma Partners - Thu, 23 Jul 2020 20:15:33 +0000