Submission Details
Molecule(s):
N=C(Nc1ccc(F)cc1)Nc1cccnc1
CC(=O)N1CCN(CNC(=N)Nc2ccc(F)cc2)CC1
CC(=O)N1CCN(CNC(=N)Nc2csc(Cl)c2)CC1
N=C(Nc1cccnc1)Nc1csc(Cl)c1
Design Rationale:
Combining features of X_0434 (versatile synthetic core) with those of X_1418 and X_1334 but incorporating a guanidine moeity instead of a urea. Adding a p-F to the aromatic system to increase metabolic stability and the CH3CO in the piperazine ring to control basicity.