Submission Details

ALP-UNI-8d415491
Molecule(s):
O=C(Nc1cnccc1C1CC1)C1CCNc2cc(Cl)c(Cl)cc21

ALP-UNI-8d415491-1

O=C(Nc1cnccc1C1CC1)C1CCNc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Nc1cncc2c1CCCC2)C1CCNc2cc(Cl)c(Cl)cc21

ALP-UNI-8d415491-2

O=C(Nc1cncc2c1CCCC2)C1CCNc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Nc1cncc2cnccc12)C1CCNc2cc(Cl)c(Cl)cc21

ALP-UNI-8d415491-3

O=C(Nc1cncc2cnccc12)C1CCNc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Nc1cncc2ccncc12)C1CCNc2cc(Cl)c(Cl)cc21

ALP-UNI-8d415491-4

O=C(Nc1cncc2ccncc12)C1CCNc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
CS(=O)(=O)c1ccc2cncc(NC(=O)C3CCNc4cc(Cl)c(Cl)cc43)c2c1

ALP-UNI-8d415491-5

CS(=O)(=O)c1ccc2cncc(NC(=O)C3CCNc4cc(Cl)c(Cl)cc43)c2c1

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Nc1cncc2ccc(F)cc12)C1CCNc2cc(Cl)c(Cl)cc21

ALP-UNI-8d415491-6

O=C(Nc1cncc2ccc(F)cc12)C1CCNc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
Design Rationale:

Varying P1 for ADME, with the most potent P2 part.

Discussion:

Contributor: Alpha Lee, University of Cambridge - Tue, 02 Mar 2021 15:08:30 +0000