O=C1NC2(CNCc3ccc(Cl)cc32)C(=O)N1c1cncc2ccccc12
O=C1N[C@@]2(CNCc3ccc(Cl)cc32)C(=O)N1c1cncc2ccccc12
CNC(=O)CN1Cc2ccc(Cl)cc2[C@@]2(C1)NC(=O)N(c1cncc3ccccc13)C2=O
NC(=O)CN1Cc2ccc(Cl)cc2[C@@]2(C1)NC(=O)N(c1cncc3ccccc13)C2=O
Try to improve potency for spirocyclic design by exploring P4 subpocket.
The first design is two step synthesis on Manifold.