Submission Details

BRU-LEF-8bac3ce8

Molecule(s):

C=CC(=O)N(c1ccc(C(F)(F)F)cc1)C(C(=O)Nc1ccccn1)c1cccnc1

BRU-LEF-8bac3ce8-1

C=CC(=O)N(c1ccc(C(F)(F)F)cc1)C(C(=O)Nc1ccccn1)c1cccnc1

Ugi Check Availability on Manifold View

Design Rationale:

close analog of active acrylamide LON-WEI-b8d-27. Replace aniline with 2-pyridyl. Lower LogD, removes aniline

Inspired By:

CS(=O)(=O)NCCc1ccccc1

AAR-POS-d2a4d1df-1

Discussion:

Contributor: Bruce a Lefker, Lefker Biopharmaconsulting LLC - Tue, 05 May 2020 01:04:17 +0000