Submission Details

NAU-LAT-8502cac5
Molecule(s):
CC(C)n1c(NC(=O)C2CCOc3ccccc32)nc2ccccc21

NAU-LAT-8502cac5-1

CC(C)n1c(NC(=O)C2CCOc3ccccc32)nc2ccccc21

3-aminopyridine-like Made Check Availability on Manifold View
O=C(Nc1nncn1C1CC1)C1COc2ccc(Cl)cc21

NAU-LAT-8502cac5-2

O=C(Nc1nncn1C1CC1)C1COc2ccc(Cl)cc21

3-aminopyridine-like Made Check Availability on Manifold View
O=C(Nc1nncn1C1CC1)C1COc2ccc(Cl)cc2C1

NAU-LAT-8502cac5-3

O=C(Nc1nncn1C1CC1)C1COc2ccc(Cl)cc2C1

O=C(Nc1nncn1C1CC1)C1c2ccccc2Oc2ccccc21

NAU-LAT-8502cac5-4

O=C(Nc1nncn1C1CC1)C1c2ccccc2Oc2ccccc21

3-aminopyridine-like Check Availability on Manifold View
CC1(C)CC(C(=O)Nc2nncn2C2CC2)c2ccccc2O1

NAU-LAT-8502cac5-5

CC1(C)CC(C(=O)Nc2nncn2C2CC2)c2ccccc2O1

3-aminopyridine-like Made Check Availability on Manifold View
O=C(Nc1nncn1-c1ccccc1)C1COc2ccc(Cl)cc21

NAU-LAT-8502cac5-6

O=C(Nc1nncn1-c1ccccc1)C1COc2ccc(Cl)cc21

3-aminopyridine-like Made Check Availability on Manifold View
Cc1ccn2cnnc2c1NC(=O)C1CCOc2ccccc21

NAU-LAT-8502cac5-7

Cc1ccn2cnnc2c1NC(=O)C1CCOc2ccccc21

3-aminopyridine-like Made Check Availability on Manifold View
O=C(Nc1nncn1C1CC1)C1CCS(=O)(=O)c2ccccc21

NAU-LAT-8502cac5-8

O=C(Nc1nncn1C1CC1)C1CCS(=O)(=O)c2ccccc21

3-aminopyridine-like Assayed Check Availability on Manifold View
CC(C)n1cnnc1CNC(=O)C1CCOc2ccccc21

NAU-LAT-8502cac5-9

CC(C)n1cnnc1CNC(=O)C1CCOc2ccccc21

CN1C(=O)CN=C1NC(=O)C1CCOc2ccc(Cl)cc21

NAU-LAT-8502cac5-10

CN1C(=O)CN=C1NC(=O)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1nccn1C1CC1)C1CCOc2ccc(Cl)cc21

NAU-LAT-8502cac5-11

O=C(Nc1nccn1C1CC1)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1n[nH]c(C2CC2)n1)C1CCOc2ccc(Cl)cc21

NAU-LAT-8502cac5-12

O=C(Nc1n[nH]c(C2CC2)n1)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
COCc1n[nH]c(NC(=O)C2CCOc3ccc(Cl)cc32)n1

NAU-LAT-8502cac5-13

COCc1n[nH]c(NC(=O)C2CCOc3ccc(Cl)cc32)n1

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C(Nc1cnc2n1CCOC2)C1CCOc2ccc(Cl)cc21

NAU-LAT-8502cac5-14

O=C(Nc1cnc2n1CCOC2)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C(Nc1ncn(C2CC2)n1)C1CCOc2ccc(Cl)cc21

NAU-LAT-8502cac5-15

O=C(Nc1ncn(C2CC2)n1)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
CC(C)n1ncnc1NC(=O)C1CCOc2ccc(Cl)cc21

NAU-LAT-8502cac5-16

CC(C)n1ncnc1NC(=O)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
Design Rationale:

Expansion/bioisosteric replacements/scaffold hopping of an early lead JAG-UCB-a3ef7265-20. All compounds should be available in Enamine REAL.

Inspired By:
Discussion:

Contributor: Nauris Narvaiss, Latvian Institute of Organic Synthesis - Sun, 21 Jun 2020 23:18:20 +0000