Submission Details

Molecule(s):
CC(=O)NC=Cc1c[nH]c2c(CN3CCC(O)CC3)cc(F)cc12

SAM-UNK-83e03154-1

CC(=O)NC=Cc1c[nH]c2c(CN3CCC(O)CC3)cc(F)cc12

CC(=O)NC=Cc1c[nH]c2c(CCNS(C)(=O)=O)cc(F)cc12

SAM-UNK-83e03154-2

CC(=O)NC=Cc1c[nH]c2c(CCNS(C)(=O)=O)cc(F)cc12

CC(=O)NC=Cc1c[nH]c2c(C=CNS(C)(=O)=O)cc(F)cc12

SAM-UNK-83e03154-3

CC(=O)NC=Cc1c[nH]c2c(C=CNS(C)(=O)=O)cc(F)cc12


Design Rationale:

Adaptations of submissions SAM-UNK-903-1 and SAM-UNK-903-2 to introduce greater rigidity and therefore reduce the entropic penalty of binding.

Inspired By:
Discussion: