Submission Details
Molecule(s):
CC(=O)NC=Cc1c[nH]c2c(CN3CCC(O)CC3)cc(F)cc12
CC(=O)NC=Cc1c[nH]c2c(CCNS(C)(=O)=O)cc(F)cc12
CC(=O)NC=Cc1c[nH]c2c(C=CNS(C)(=O)=O)cc(F)cc12
Design Rationale:
Adaptations of submissions SAM-UNK-903-1 and SAM-UNK-903-2 to introduce greater rigidity and therefore reduce the entropic penalty of binding.