Submission Details

MIC-UNK-8373f97b
Molecule(s):
NC(=O)NC1(CC(=O)Nc2cccc(Cl)c2)C(=O)Nc2ccccc21

MIC-UNK-8373f97b-1

NC(=O)NC1(CC(=O)Nc2cccc(Cl)c2)C(=O)Nc2ccccc21

3-aminopyridine-like Check Availability on Manifold View
NC(=O)CC1(NC(=O)Cc2cccc(Cl)c2)C(=O)Nc2ccccc21

MIC-UNK-8373f97b-2

NC(=O)CC1(NC(=O)Cc2cccc(Cl)c2)C(=O)Nc2ccccc21

C[S+]([O-])CC1(CC(=O)Nc2cccc(Cl)c2)C(=O)Nc2ccccc21

MIC-UNK-8373f97b-3

C[S+]([O-])CC1(CC(=O)Nc2cccc(Cl)c2)C(=O)Nc2ccccc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Cc1cccc(Cl)c1)NC1C(=O)NC2CCCCC21

MIC-UNK-8373f97b-4

O=C(Cc1cccc(Cl)c1)NC1C(=O)NC2CCCCC21

O=C(Cc1cccc(Cl)c1)NC1C(=O)NC2CCCC21

MIC-UNK-8373f97b-5

O=C(Cc1cccc(Cl)c1)NC1C(=O)NC2CCCC21

Design Rationale:

At first I just wanted to add some lipophilicity to butyrolactams, but then I noticed that extending butyrolactone a bit it can reach Gly143 like quinolones

Other Notes:

First three should be synthetizable from isatin

Discussion:

Contributor: Michal K - Sun, 09 Aug 2020 00:09:44 +0000