Submission Details

EDJ-MED-82bd779b

Molecule(s):

COC1(CS(=O)(=O)N2Cc3ccc(Cl)cc3C(C)(C(=O)Nc3cncc4ccccc34)C2)CC1

EDJ-MED-82bd779b-1

COC1(CS(=O)(=O)N2Cc3ccc(Cl)cc3C(C)(C(=O)Nc3cncc4ccccc34)C2)CC1

3-aminopyridine-like Ordered Check Availability on Manifold View

Design Rationale:

Replacement of cyclopropyl nitrile with methoxy for chemical synthesis and possible PXR liability

Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Fri, 17 Sep 2021 17:03:35 +0000