Submission Details
Molecule(s):
CC(C)(C)c1ccc(N(C(=O)c2ccco2)C(C(=O)NCCc2cccc(F)c2)c2cncc3cccnc23)cc1
CC(C)(C)c1ccc(N(C(=O)c2ccco2)C(C(=O)NCCc2cccc(F)c2)c2cncc3scnc23)cc1
Design Rationale:
Maybe internal hydrogen bond between quinoline nitrogen and amide will form, at the same time stabilizing entire structure and providing additional contact surface (like in isoquinolines). Azabenzothiazole derivative in case that weaker, less basic hydrogen bond acceptor was needed.