Submission Details

Molecule(s):
O=c1c(O)c(-c2ccc(O)cc2)oc2c(O)c(O)cc(O)c12

VIR-GIT-7b3d3065-1

O=c1c(O)c(-c2ccc(O)cc2)oc2c(O)c(O)cc(O)c12

O=C(CCl)N1CCC(C(=O)N2CCCCC2)CC1

VIR-GIT-7b3d3065-2

O=C(CCl)N1CCC(C(=O)N2CCCCC2)CC1

CC(C)N(C)C(=O)C1CCN(C(=O)CCl)CC1

VIR-GIT-7b3d3065-3

CC(C)N(C)C(=O)C1CCN(C(=O)CCl)CC1


Design Rationale:

Description: PCM-012781 ? PCM-0102972 ClCC(=O)N1CCC(CC1)C(=O)N2CCCCC2 PCM-0102974 CC(C)N(C)C(=O)C1CCN(CC1)C(=O)CCl piperidine-amides for MPro The aniline substitution seems especially potent

Other Notes:

submitted on Fragalysis (github)

Inspired By:
Discussion: