O=C(CCl)C1CCN(S(=O)(=O)c2cccs2)CC1
O=C(CCl)C1CCN(S(=O)(=O)c2c(F)cccc2F)CC1
O=C(CCl)N1CCN(Cc2cccc(F)c2)C(=O)C1
O=C(c1cccc(F)c1)C1CCN(C(=O)CCl)CC1
O=C(CCl)C1CCN(S(=O)(=O)c2cccc(F)c2)CC1
O=C(CCl)N1CCC(S(=O)(=O)c2cccc(F)c2)CC1
O=C(CCl)N1CCCN(C(=O)c2c(F)cccc2F)CC1
O=C(CCl)N1CCCN(S(=O)(=O)Cc2ccccc2)CC1
O=C(CCl)N1CCCN(S(=O)(=O)c2cc(F)ccc2F)CC1
O=C(CCl)N1CCCN(S(=O)(=O)c2ccccc2F)CC1
O=C(CCl)N1CCCN(S(=O)(=O)c2c(F)cccc2F)CC1
O=C(CCl)N1CCCN(S(=O)(=O)c2cccs2)CC1
O=C(CCl)N1CCCN(S(=O)(=O)c2cccc(F)c2)CC1
Based on AAR-POS-d2a4d1df-22, but changing the core to 7 membered rings , removing one of the piperazine nitrogens, or changing the linker to amide or alkyl
Componuds will be submitted for synthesis in the DNDi Open synthesis Network (OSN)