Elongation of side chain in order to be better fitted into a supposed hydrophobic subpocket, as observed by activity of derivatives SIM-SYN-f15aaa3a-1 and GIA-UNK-20b63697-6. As observed, hydrophilic substitution, as GIA-UNK-20b63697-2, causes drop of biological activity. Small and larger hydrophobic substituents, in various orientation, are provided.
Same synthesis of GIA-UNK-20b63697-6. The phenylisoxazole derivative could be synthesized from acetophenone.