Submission Details
Molecule(s):
C[Si](C)(C)Oc1ccc(S(N)(=O)=O)cc1
CC[Si](C)(C)Oc1ccc(S(N)(=O)=O)cc1
COc1ccc(S(N)(=O)=O)cc1
Design Rationale:
By eye, combined X0161 with PDB 2Q6G's Leu5 (chain D) bound to active site. Replace ester in X0161 with sp3 centre and extend to fill Leu5-occupied pocket in PDB file 2Q6G.