Submission Details

MIC-UNK-6e9f8a43
Molecule(s):
CSC1(C(=O)Nc2cncc3ccccc23)CN(S(C)(=O)=O)Cc2ccc(Cl)cc21

MIC-UNK-6e9f8a43-1

CSC1(C(=O)Nc2cncc3ccccc23)CN(S(C)(=O)=O)Cc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CSC1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21

MIC-UNK-6e9f8a43-2

CSC1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Sulfur-based analogues of PET-UNK-29afea89-2 and PET-UNK-9bf1291a-1. As thiolates are more powerful nucleophiles than alkoxylates, synthesis could be easier compared to ether counterparts. Chromane mostly for comparison. If high activity of PET-UNK-29afea89-2 depends on intramolecular hydrogen bond, I don't expect these compounds to be particularly potent.

Inspired By:
Discussion:

Contributor: Michal K - Mon, 05 Apr 2021 21:29:11 +0000