Submission Details

EDJ-MED-6d9ff7d0
Molecule(s):
COCCCCN[C@]1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21

EDJ-MED-6d9ff7d0-1

COCCCCN[C@]1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)[C@@]1(NCCc2ccn[nH]2)CCOc2ccc(Cl)cc21

EDJ-MED-6d9ff7d0-2

O=C(Nc1cncc2ccccc12)[C@@]1(NCCc2ccn[nH]2)CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)[C@@]1(NCc2ccn[nH]2)CCOc2ccc(Cl)cc21

EDJ-MED-6d9ff7d0-3

O=C(Nc1cncc2ccccc12)[C@@]1(NCc2ccn[nH]2)CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
COCCCN[C@]1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21

EDJ-MED-6d9ff7d0-4

COCCCN[C@]1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)[C@@]1(NCCc2ccccn2)CCOc2ccc(Cl)cc21

EDJ-MED-6d9ff7d0-5

O=C(Nc1cncc2ccccc12)[C@@]1(NCCc2ccccn2)CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)[C@@]1(NCc2ccccn2)CCOc2ccc(Cl)cc21

EDJ-MED-6d9ff7d0-6

O=C(Nc1cncc2ccccc12)[C@@]1(NCc2ccccn2)CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C1CCC(CCN[C@]2(C(=O)Nc3cncc4ccccc34)CCOc3ccc(Cl)cc32)N1

EDJ-MED-6d9ff7d0-7

O=C1CCC(CCN[C@]2(C(=O)Nc3cncc4ccccc34)CCOc3ccc(Cl)cc32)N1

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C1CCC(CN[C@]2(C(=O)Nc3cncc4ccccc34)CCOc3ccc(Cl)cc32)N1

EDJ-MED-6d9ff7d0-8

O=C1CCC(CN[C@]2(C(=O)Nc3cncc4ccccc34)CCOc3ccc(Cl)cc32)N1

3-aminopyridine-like Ordered Check Availability on Manifold View
CS(=O)(=O)CCN[C@@]1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21

EDJ-MED-6d9ff7d0-9

CS(=O)(=O)CCN[C@@]1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
CS(=O)(=O)CCCN[C@@]1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21

EDJ-MED-6d9ff7d0-10

CS(=O)(=O)CCCN[C@@]1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
Design Rationale:

Design based on high FEP scoring compound VLA-UCB-34F3ED0C-16 and Peter Kenny design PET-UNK-4880b143-1. Recognising the added potency exhibited by MAT-POS-3b97339c-2 as a preferred linker and targeting reductive amination as the chemistry from MAT-POS-3b97339c-2.Some variation on chain length to test SAR.

Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Tue, 23 Feb 2021 20:40:36 +0000