Submission Details
Molecule(s):
NC(N)=Nc1nc(CSCCC(N)=NS(N)(=O)=O)cs1
CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1
CN=C(NC#N)NCCSCc1nc[nH]c1C
CNC(=S)NCCCCc1c[nH]cn1
Design Rationale:
Famotidine is a known H2 Antagonist and a drug originally marketed for the treatment of stomach ulcers. It has been reported https://doi.org/10.1101/2020.05.01.20086694 has being of therapeutic value in the treatment of Covid-19 as proposed by Dr C Wu et al in Acta Pharm Sin B. 2020. Ranitidine, Cimetidine and Burimamide are also H2 Antagonists and such molecules have also been reported to have anti-viral properties by A S Bourinbaiar & E C Fruhstorfer Life Sci. 1996;59(23):PL 365-70.
Other Notes:
Burimamide wasnt marketed as a H2 Antagonist and is more active as a H3 antagonist.