Submission Details

SEA-TRI-6cb4f71a

Molecule(s):

C=CS(=O)(=O)N1CCN([C@@H](c2cc(Cl)cc(CCS(N)(=O)=O)c2)c2cccs2)CC1

SEA-TRI-6cb4f71a-1

C=CS(=O)(=O)N1CCN([C@@H](c2cc(Cl)cc(CCS(N)(=O)=O)c2)c2cccs2)CC1

Check Availability on Manifold View

Design Rationale:

Fragment linking Extending into region bound by sulfonamide reversible binders Vinyl sulfone Michael acceptor Part by eye, part by SeeSAR

Other Notes:

SMcK-013

Inspired By:

COC(=O)c1ccc(S(N)(=O)=O)cc1

MAT-POS-7dfc56d9-1

O=C(CCl)N1CCN(Cc2cccc(Cl)c2)CC1

MED-COV-4280ac29-15

Discussion:

Contributor: Sean McKenna, Trinity College Dublin - Thu, 02 Apr 2020 09:30:13 +0000