Submission Details

Molecule(s):
O=C(CCl)N1CCN(C(=O)c2cccc3ccccc23)CC1

MAK-UNK-6ca90168-1

O=C(CCl)N1CCN(C(=O)c2cccc3ccccc23)CC1

piperazine-chloroacetamide Check Availability on Manifold View
C=CC(=O)N1CCN(C(=O)c2cccc3ccccc23)CC1

MAK-UNK-6ca90168-2

C=CC(=O)N1CCN(C(=O)c2cccc3ccccc23)CC1

C=Cc1ccccc1C(=O)C(=O)N1CCN(C(=O)CCl)CC1

MAK-UNK-6ca90168-3

C=Cc1ccccc1C(=O)C(=O)N1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
Cc1ccccc1C(=O)C(=O)N1CCN(C(=O)CCl)CC1

MAK-UNK-6ca90168-4

Cc1ccccc1C(=O)C(=O)N1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
C#Cc1ccccc1C(=O)C(=O)N1CCN(C(=O)CCl)CC1

MAK-UNK-6ca90168-5

C#Cc1ccccc1C(=O)C(=O)N1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
N#Cc1ccccc1C(=O)C(=O)N1CCN(C(=O)CCl)CC1

MAK-UNK-6ca90168-6

N#Cc1ccccc1C(=O)C(=O)N1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
CC(C(=O)N1CCN(C(=O)CCl)CC1)c1ccccc1C#N

MAK-UNK-6ca90168-7

CC(C(=O)N1CCN(C(=O)CCl)CC1)c1ccccc1C#N

piperazine-chloroacetamide Check Availability on Manifold View
N#Cc1ccccc1C(Cl)C(=O)N1CCN(C(=O)CCl)CC1

MAK-UNK-6ca90168-8

N#Cc1ccccc1C(Cl)C(=O)N1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
N#Cc1ccccc1CC(=O)N1CCN(C(=O)CCl)CC1

MAK-UNK-6ca90168-9

N#Cc1ccccc1CC(=O)N1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
Cc1ccccc1CC(=O)N1CCN(C(=O)CCl)CC1

MAK-UNK-6ca90168-10

Cc1ccccc1CC(=O)N1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
O=C(CCl)N1CCC(C(c2ccccc2)c2ccccc2)CC1

MAK-UNK-6ca90168-11

O=C(CCl)N1CCC(C(c2ccccc2)c2ccccc2)CC1

C=CC(=O)N1CCN(C(c2ccccc2)c2ccccc2)CC1

MAK-UNK-6ca90168-12

C=CC(=O)N1CCN(C(c2ccccc2)c2ccccc2)CC1

C=CC(=O)N1CCN(Cc2cccc(Cl)c2)CC1

MAK-UNK-6ca90168-13

C=CC(=O)N1CCN(Cc2cccc(Cl)c2)CC1

N#Cc1ccc(CN2CCN(C(=O)CCl)CC2)cc1

MAK-UNK-6ca90168-14

N#Cc1ccc(CN2CCN(C(=O)CCl)CC2)cc1

piperazine-chloroacetamide Check Availability on Manifold View
O=C(CCl)N1CCN(C(=O)c2cccc(Cl)c2)CC1

MAK-UNK-6ca90168-15

O=C(CCl)N1CCN(C(=O)c2cccc(Cl)c2)CC1

piperazine-chloroacetamide Check Availability on Manifold View
C=CC(=O)N1CCN(C(=O)CCl)CC1

MAK-UNK-6ca90168-16

C=CC(=O)N1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
N#CC(=O)N1CCN(C(=O)CCl)CC1

MAK-UNK-6ca90168-17

N#CC(=O)N1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
N#CCC(=O)N1CCN(C(=O)CCl)CC1

MAK-UNK-6ca90168-18

N#CCC(=O)N1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
O=C(CCl)N1CCN(C(=O)c2ccsc2)CC1

MAK-UNK-6ca90168-20

O=C(CCl)N1CCN(C(=O)c2ccsc2)CC1

piperazine-chloroacetamide Check Availability on Manifold View
N#CC(c1ccsc1)C1CCN(C(=O)CCl)CC1

MAK-UNK-6ca90168-22

N#CC(c1ccsc1)C1CCN(C(=O)CCl)CC1

N#Cc1ccncc1NC(=O)Cc1cccc(Cl)c1

MAK-UNK-6ca90168-23

N#Cc1ccncc1NC(=O)Cc1cccc(Cl)c1

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1NC(=O)C(=O)c1cccc(Cl)c1

MAK-UNK-6ca90168-24

Cc1ccncc1NC(=O)C(=O)c1cccc(Cl)c1

3-aminopyridine-like Check Availability on Manifold View
N#Cc1cccc(NC(=O)C(=O)c2cncc3ccccc23)c1

MAK-UNK-6ca90168-25

N#Cc1cccc(NC(=O)C(=O)c2cncc3ccccc23)c1

3-aminopyridine-like Check Availability on Manifold View

Design Rationale:

by eye, modified best sorted molecules by Average Inhibition @ 50 ┬ÁM

Inspired By:
Discussion: