Submission Details

JOH-UNI-6b98e24c
Molecule(s):
CC(C)NC(=O)CN1C[C@@H](C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

JOH-UNI-6b98e24c-1

CC(C)NC(=O)CN1C[C@@H](C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

CNC(=O)C(C(C)C)N1C[C@@H](C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

JOH-UNI-6b98e24c-2

CNC(=O)C(C(C)C)N1C[C@@H](C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

CNC(=O)CN1C[C@@H](C(=O)Nc2c(C(F)F)ncc3ccccc23)c2cc(Cl)ccc2C1=O

JOH-UNI-6b98e24c-3

CNC(=O)CN1C[C@@H](C(=O)Nc2c(C(F)F)ncc3ccccc23)c2cc(Cl)ccc2C1=O

Design Rationale:

A few exemplars for potentially addressing metabolism: replace glycine with other amino acids. Replace NMe with bulkier amine groups Protection ortho quinoline

Discussion:

Contributor: John Spencer, University of Sussex - Sat, 25 Dec 2021 19:16:28 +0000