Submission Details

EDJ-MED-6ab52e52
Molecule(s):
O=C(Cc1cccc(Cl)c1)Nc1cncc2cccc(Cl)c12

EDJ-MED-6ab52e52-1
Duplicate of:
MIC-UNK-50cce87d-2

O=C(Cc1cccc(Cl)c1)Nc1cncc2cccc(Cl)c12

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
Design Rationale:

RUB-POS-1325a9ea-2/MIC-UNK-50cce87d-1 (5-F) is 1.6x worse than ADA-UCB-6c2cb422-1(5-H) and 4x worse than MIC-UNK-50cce87d-3 (5-Me), therefore can we generate a 5 electron withdrawing substituent (metabolism and Ames) that confers more potency.

Inspired By:
Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Wed, 04 Aug 2021 14:28:00 +0000