Submission Details

JOO-IND-68bcc4bc
Molecule(s):
Design Rationale:

Fragment 0749 is nicely positioned for alternative warheads. Here I have replaced the chloroacetamide with a more drug-like nitrile. Cyclohexane nitrile is readily available as building block.

Inspired By:
Discussion:

Contributor: Joost Uitdehaag, industry - Sun, 29 Mar 2020 14:11:03 +0000