Submission Details
Molecule(s):
Cn1nncc1CC(=O)N[C@@H](c1ccccc1)c1nc2ccccc2n1C
Cn1c([C@@H](NC(=O)Cc2ccncc2)c2ccccc2)nc2ccccc21
Cn1nncc1CC(=O)N[C@@H](c1ccc(Cl)cc1)c1nc2ccccc2n1C
Cn1c([C@@H](NC(=O)Cc2ccncc2)c2ccc(Cl)cc2)nc2ccccc21
Cn1c([C@@H](NC(=O)Cc2cnnn2CN)c2ccccc2)nc2ccccc21
Cn1c([C@@H](NC(=O)Cc2cnnn2CN2CCC2)c2ccccc2)nc2ccccc21
CNCn1nncc1CC(=O)N[C@@H](c1ccccc1)c1nc2ccccc2n1C
Design Rationale:
Some Ideas around BAR-COM-4e090d3a-6 & TRY-UNI-714-6: 1. Chiral pure form 2. pyridine version 3. Cl version 4. 2+3 5. Adding charge to target GLU166 6. Adding charge to target GLU166 7. Adding charge to target GLU166