Designed using Evariste's proprietary platform, Frobenius. In this case, utilising ligand data only, not structural information. Model built using fluorescence IC50 data available as of 12/01/20, irreversible inhibitors included. Compound used as starting point for further design in all cases was MAT-POS-53907a1c-3. First three molecules are the highest scoring designs (of all submitted by Evariste) by approx 5-fold.