Submission Details

FRA-DIA-6238d354
Molecule(s):
CO[C@@]1(C(=O)Nc2cncc3ccc(S(C)(=O)=O)cc23)CN(S(C)(=O)=O)Cc2ccc(Cl)cc21

FRA-DIA-6238d354-1

CO[C@@]1(C(=O)Nc2cncc3ccc(S(C)(=O)=O)cc23)CN(S(C)(=O)=O)Cc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CS(=O)(=O)c1ccc2cncc(NC(=O)C3CN(S(C)(=O)=O)Cc4ccc(Cl)cc43)c2c1

FRA-DIA-6238d354-2

CS(=O)(=O)c1ccc2cncc(NC(=O)C3CN(S(C)(=O)=O)Cc4ccc(Cl)cc43)c2c1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Blend of two potent sulfones, one ~100nM, the other ~520nM. And wang on that senational 80nM quaternary methoxy while we're at it.

Inspired By:
Discussion:

Contributor: Frank von Delft, Diamond Light Source - Mon, 22 Mar 2021 20:45:21 +0000