Submission Details
Molecule(s):
O=c1[nH]c(Cc2cccc(Cl)c2)nc2cnccc12
O=c1[nH]c(Cc2cccc(C(F)(F)F)c2)nc2cnccc12
O=c1[nH]c(Cc2cccc(S(F)(F)(F)(F)F)c2)nc2cnccc12
COC(=O)c1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1
Design Rationale:
Unexpected products, (CF3) confirmed by xray structure. Open form synthesis is being perfomed (amidation of ester under forced conditions led to ring closure).
Other Notes:
To be submitted shortly, made in our lab by PhD and postdocs (Arathy Jose and Dr Dan Guest)