Submission Details

RAL-THA-5ed3c24e
Molecule(s):
O=C(Nc1nncn1C1CC1)C1CCCc2ccc(Cl)cc21

RAL-THA-5ed3c24e-1

O=C(Nc1nncn1C1CC1)C1CCCc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CN1CC(C(=O)Nc2nncn2C2CC2)c2cc(Cl)ccc2C1=O

RAL-THA-5ed3c24e-2

CN1CC(C(=O)Nc2nncn2C2CC2)c2cc(Cl)ccc2C1=O

3-aminopyridine-like Check Availability on Manifold View
O=C1NCC(C(=O)Nc2nncn2C2CC2)c2cc(Cl)ccc21

RAL-THA-5ed3c24e-3

O=C1NCC(C(=O)Nc2nncn2C2CC2)c2cc(Cl)ccc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Expansion of early lead JAG-UCB-a3ef7265-20. Examine role of the pyran O atom in potency and possible replacement with an amide.

Inspired By:
Discussion:

Contributor: Ralph Robinson, Thames Pharma Partners - Fri, 26 Jun 2020 14:27:31 +0000