Submission Details
Molecule(s):
O=C(S)C1CCN(C(=O)c2ccccc2)CC1
O=C(S)C1CCN(C(=O)C2CCCCC2)CC1
O=C(S)C1CCN(Cc2ccccc2)CC1
O=C(S)C1CCN(S(=O)(=O)c2ccccc2)CC1
O=C(S)C1CCN(C(=O)Cc2ccccc2)CC1
Design Rationale:
Eye. Replacement of the chloromethylene group with a thiocarboxylic acid. Aimed covalently bond with sulfur of proximal cysteine.
Other Notes:
Simple synthesis, couplings and formation of thiocarboxylic acid. Some of them think already available in some chemical libraries.