Submission Details
Molecule(s):
CC(=O)C(=O)N1CCN(S(=O)(=O)c2cccc(F)c2)CC1
Design Rationale:
The ketoamide is an alternative warhead in place of the alpha chloroamide. There should be enough room in the pocket to form a covalent bond with the active site Cysteine and still maintain all of the rest of the interaction points for this fragment.